Heterogeneity of microglial proton channel in different brain regions and its relationship with aging

The properties of microglia largely differ depending on aging as well brain regions. However, there are few studies that investigated the functional importance such heterogeneous at molecular level. Voltage-gated proton channel, Hv1/VSOP, could be one candidates which confers heterogeneity among since it regulates oxidative stress in age-dependent manner. In this study, we found Hv1/VSOP shows region-dependent gene expression with highest level striatum. We studied two different regions, cerebral cortex and striatum, examined their relationship (using mice ages). cortex, observed impact stress, microglial morphology, profile. On other hand, significance was less obvious striatum than cortex. Finally, performed a battery behavioral experiments Hv1/VSOP-deficient both young aged stages to examine effect function. specifically showed marked difference behavior light/dark transition test only stages, indicating anxiety state is altered mice. This study suggests combination region animal underscores microglia.